Comparison of the Efficacy of Three Progestins in the Treatment of Simple Endometrial Hyperplasia without Atypia

Aim: To evaluate the treatment of endometrial hyperplasia (EH) with different progestins. Methods: Eighty-two women with simple EH without atypia were included. Patients were offered oral progestagens and were randomized to one of three options for 3 months: medroxyprogesterone acetate (MPA, 10 mg/day), lynestrenol (LYN, 15 mg/day) and norethisterone (NET, 15 mg/day) for 10 days per cycle. Patients were reevaluated after treatment. Women diagnosed with proliferative and nonatypical EH at the second curettage were offered the same progestins for another 3 months. The primary outcome of the study was the proportion of women requiring further treatment. Results: Of the 82 women, 46 (56.1%) received MPA (23.2%), LYN (13.4%) and NET (19.5%) therapy for another 3 months at the end of the first 3 months of treatment. The patients receiving MPA showed resolution in 36.7% of the cases versus 37% in the NET group. The highest resolution rate (56%) was observed in the LYN group, although there was no statistically significant difference between progestins regarding the proportion of women reReceived: March 31, 2010 Accepted after revision: September 22, 2010 Published online: January 25, 2011 Ozlem Ozdegirmenci, MD Etlik Zubeyde Hanim Women’s Health Teaching and Research Hospital TR–06510 Ankara (Turkey) Tel. +90 312 221 38 99, Fax +90 312 323 81 91 E-Mail ozlemerman @ gmail.com © 2011 S. Karger AG, Basel 0378–7346/11/0721–0010$38.00/0 Accessible online at: www.karger.com/goi D ow nl oa de d by : 54 .7 0. 40 .1 1 10 /6 /2 01 7 5: 20 :3 8 A M